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Transcriptional Factors And Regulators

All the cellular processes in living cells such as growth, development, morphogenesis and cellular differentiation are a product of gene expression programs involving complicated transcriptional regulation of several genes. This process of transcriptional regulation is tightly controlled and coordinated by proteins called transcriptional regulators.

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Folate Receptor 4 (FR4)

Folates play an important role in protein and nucleic acid biosynthesis and are particularly recognized for their roles in spinal canal and brain development during early pregnancy.

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Neuropilin-1/BDCA-4/CD304

Neuropilin-1 (Nrp-1) was recently identified as a possible surface marker for naturally occurring CD4+CD25+ regulatory T cells and is constitutively expressed on the cell irrespective of its activation status.

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A Functional Contributor to Cancer Metastatic Potential

Tumor metastasis plays a key role in assessing treatment strategies and an important factor in determining patient prognosis. Not surprisingly, significant effort has been focused on elucidating the molecular basis behind tumor metastasis.

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In Search of Putative FOXP3+ Cell Surface Markers

Flow cytometric analysis of intracellular FOXP3 (IMG-5802D) and cell surface FR4 with clone 12A5 (IMG-6217C) (left) and clone TH6 (IMG-6218C) (right) at 0.06 ug/10^6 mouse splenocytes.

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TLR10- cluster of differentiation 290

Toll-like receptor 10 (TLR10) often known as CD290 (cluster of differentiation 290), is the most recently identified human homolog of the Drosophila TOLL protein.

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TLR9- cluster of differentiation 289

Toll-like receptor 9 (TLR9) often known as CD289 (cluster of differentiation 289), is a member of the Toll-like receptor family that recognizes pathogen-associated molecular pattern.

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TLR8- cluster of differentiation 288

Toll-like receptor 8 (TLR8) often designated as CD288 (cluster of differentiation 288) is a member of evolutionarily conserved Toll-like receptor family which are critical parts of the evolutionarily conserved innate immune system.

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TLR7- cluster of differentiation 287

Toll-like receptor 7 (TLR7), is an immune gene possessed by humans, other mammals and additionally in avian species playing a significant role in initiating antiviral immune responses.

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TLR6- cluster of differentiation 286

Toll-like receptor 6 (TLR6) often designated as CD286 (cluster of differentiation 286), is a member of the Toll-like receptor family, a highly conserved series of ancient innate immune pattern recognition receptors.

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TLR5- cluster of differentiation 285

Toll-like receptor 5 (TLR5), a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens.

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TLR4- cluster of differentiation 284

Toll-like receptor 4 (TLR4) often designated as CD284 (cluster of differentiation 284) is a class I transmembrane receptor belonging to the large homologous family of Toll like receptors.

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TLR3- cluster of differentiation 283

Toll-like receptor 3 (TLR3) often designated as CD283 (cluster of differentiation 283) is a type I transmembrane receptor protein.

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TLR2- cluster of differentiation 282

Toll-like receptor 2 (TLR2), often designated as CD282 (cluster of differentiation 282) is a type I transmembrane protein belonging to the large homologous family of Toll like receptors.

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TLR1- cluster of differentiation 281

Toll-like receptor 1 (TLR1) often designated as CD281 (cluster of differentiation 281), a member of the Toll-like receptor family recognizes pathogen-associated molecular pattern with specificity for gram-positive bacteria.

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